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There is much disagreement concerning the immunological basis of immunotherapy. A shift from T-helper 2 (Th2) to T-helper 1 immunity against allergens, the induction of regulatory T-cells suppressing Th2-activity and the induction of blocking IgG antibodies each have their advocates for being pivotal in the protective mechanism of SIT. The number of SIT studies that have included in depth immunological analyses covering all these aspects in the same trial is very limited. Indeed, for immunotherapy of food allergy such studies are not at all available. For future improvements to the efficacy of SIT, it is of the utmost importance to elucidate the mechanism of protection observed during SIT.


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